Persimmon carotenoid extract rich in β-cryptoxanthin improves glucose homeostasis and reduces liver damage in high-fat-diet-induced type 2 diabetic and metabolic dysfunction-associated steatotic liver disease mice.

ABSTRACT:

Background

Persimmon (Diospyros kaki Thunb.) byproducts are a remarkable source of bioactive compounds, particularly carotenoids. Several studies suggest that carotenoids have beneficial effects in prevention of a large number of diseases. This study aims to highlight the effects of a persimmon carotenoid extract (PSCE) rich in β-cryptoxanthin (β-CRX, 51%) in ameliorating type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) in male C57BL6J mice. Animals were fed with a low-fat diet (LFD, n = 10), a LFD plus PSCE (0.8 mg kg^-1 body weight per day; LFD-PSCE, n = 10), or a high-fat diet (HFD, n = 20), for 6 months. At the third month, 10 random mice from the HFD group were supplemented with PSCE for the remaining 3 months (HFD-

SUBMITTER: Moreno-Chamba B 

PROVIDER: S-EPMC12701299 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature