Integrative analysis identifies PIGK as an oncogenic glycosylphosphatidylinositol transamidase subunit with prognostic, immunological, and therapeutic relevance in head and neck cancer.

ABSTRACT:

Background

Glycosylphosphatidylinositol transamidase (GPI-T) catalyzes the attachment of glycosylphosphatidylinositol (GPI) anchors to membrane proteins implicated in oncogenic signaling. However, the specific contribution of individual GPI-T subunits to head and neck cancer (HNC) remains unclear.

Methods

We first compare the expression profiles of GPI-T subunits in HNC and then integrate multi-omics analyses to assess phosphatidylinositol glycan class K (PIGK) expression, genomic alterations, function and pathway enrichment, molecular interactions, and immune associations. Clinical relevance is validated by immunohistochemistry on tissue microarray, and in vitro assays were conducted to assess PIGK-mediated phenotypes, regulation of Family with seque

SUBMITTER: Yang YF 

PROVIDER: S-EPMC12701967 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature