Diffuse infiltrating retinoblastoma: a multicentre, international, data-sharing study.

ABSTRACT:

Background

To determine the unique clinical characteristics and treatment outcomes of diffuse infiltrating retinoblastoma (DIR).

Methods

This international, multicentre, registry-based retrospective case series analysed pooled data from January 2001 to December 2013, including 132 eyes from 132 patients with DIR.

Results

Among 2854 eyes with retinoblastoma, 132 (4.6%; 95% CI, 3.9 to 5.5) had DIR. The median age at diagnosis for DIR patients was 24 months (IQR, 15-33), with no bilateral cases of DIR. The American Joint Committee on Cancer staging showed 4.5% cT2 and 95.5% cT3 categories, with no cT1 or cT4 cases. Clinical features associated with DIR included secondary glaucoma (67%), retinal detachment (38%), diffuse vitreous seeds (37%), anterior segment involvement

SUBMITTER: Tomar AS 

PROVIDER: S-EPMC12703232 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature