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Ultrasensitive Test Systems Are Required to Quantify Interferon Alpha Protein in Serum Samples.

ABSTRACT: Selecting a sensitive test system is crucial to measure IFNα in serum samples. Simoa digital ELISA stands out for its high sensitivity and strong correlation with transcript-based IFN-induced gene (ISG) scores. In SLE, the ISG score is explained by circulating IFNα levels with negligible contribution from IFNβ or IFNγ. Created in BioRender.

SUBMITTER: Haljasmagi L 

PROVIDER: S-EPMC12712876 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature

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Ultrasensitive Test Systems Are Required to Quantify Interferon Alpha Protein in Serum Samples.

Haljasmägi Liis L   Meisalu Sandra S   Bondet Vincent V   Peterson Pärt P   Duffy Darragh D   Kisand Kai K  

European journal of immunology 20251201 12

Selecting a sensitive test system is crucial to measure IFNα in serum samples. Simoa digital ELISA stands out for its high sensitivity and strong correlation with transcript-based IFN-induced gene (ISG) scores. In SLE, the ISG score is explained by circulating IFNα levels with negligible contribution from IFNβ or IFNγ. Created in BioRender. ...[more]

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