Negr1 Deficiency Modulates Sex-Specific Neurobehavioral Adaptations to Social Isolation.

ABSTRACT: Objective: Neuronal growth regulator 1 (Negr1) is a GPI-anchored neuronal cell adhesion molecule of the IgLON superfamily associated with multiple psychiatric disorders. This study aimed to investigate behavioral and molecular adaptations to social isolation (SI) stress in Negr1-deficient (Negr1^-/-) mice. Methods: Male and female Negr1^-/- and wild-type (Wt) mice (n = 10 per group) were exposed to two weeks of SI or group housing (Ctl). Behavioral assays assessed exploratory and anxiety-like behavior. Gene expression analyses in the prefrontal cortex and hippocampus were performed using RT-qPCR, focusing on GABAergic, neurotrophic, and IgLON family genes. Results: SI-induced weight loss in Negr1^-/- mice

SUBMITTER: Reinsberg A 

PROVIDER: S-EPMC12730293 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature