The NLRP3 Inflammasome Regulates Orthodontic Tooth Movement.

ABSTRACT:

Objective

The NLRP3 inflammasome is a damage sensor driving pyroptotic cell death during orthodontic tooth movement (OTM). Recent studies have revealed impaired one-week OTM in mice lacking NLRP3. However, the relevance of NLRP3 during long-term OTM remains unknown.

Materials and methods

OTM was analysed after 7, 14 and 21 days of force application in mice lacking NLRP3 (NLRP3^-/-), wild-type (WT) male and female littermates. Micro-computed tomography (μCT) was used to assess molar movement and bone quality. Tartrate-resistant acid phosphatase (TRAP) staining was used to visualise osteoclastic activity.

Results

We show here that after 2 weeks of force application, OTM was delayed in mice lacking NLRP3 compared to WT mice. Interestingly, OTM regained speed in

SUBMITTER: Latzko L 

PROVIDER: S-EPMC12779247 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature