Proteomic Analysis of <i>Streptococcus suis</i> During Exposure to Intracellular Condition of Human Macrophage U937 Cells.

ABSTRACT: Streptococcus suis is an important zoonotic pathogen responsible for severe infections in pigs and humans. Its capacity to survive within phagocytic cells is considered a key virulence mechanism that contributes to dissemination and persistence in host tissues. This study employed comparative proteomic profiling to investigate intracellular adaptation of S. suis serotypes 2 (SS2) and 14 (SS14) during infection of human U937 macrophages. Five isolates originating from humans and pigs were analyzed using gel electrophoresis with liquid chromatography-tandem mass spectrometry (GeLC-MS/MS), revealing 118 differentially expressed proteins grouped into 11 functional categories. Translation-related proteins represented the largest group (48%), including upregulated ribosomal subunit

SUBMITTER: Prangsuwan P 

PROVIDER: S-EPMC12786085 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature