Exploring the Neuroprotective Properties of Capsanthin: Antioxidant Defense and Inflammatory Responses.

ABSTRACT:

Background/objectives

Capsanthin is a xanthophyll carotenoid from Capsicum species with an extended conjugated polyene chain that underlies both its orange-red color and strong antioxidant potential. In this study, we investigated whether capsanthin protects RA-differentiated SH-SY5Y neuron-like cells against glutamate-induced stress.

Methods

Neuronal dysfunction was induced by glutamate exposure, and capsanthin treatment was evaluated using cell viability, reactive oxygen species (ROS) production, antioxidant defense markers, inflammatory cytokines, mitochondrial energy status, and apoptosis-related endpoints. Antioxidant responses were assessed using superoxide dismutase, catalase, glutathione peroxidase activities, and total antioxidant capacity. Cytokine release (TNFα, I

SUBMITTER: Pap R 

PROVIDER: S-EPMC12787947 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature