Methylene Blue-Loaded Liposomal Nanocarriers Enhance the Efficacy of Photodynamic Therapy against <i>Candida auris</i> Biofilm.

ABSTRACT: Candida auris poses a significant healthcare challenge, particularly within immunosuppressed patients. This pathogen can colonize the skin and develop biofilms associated with increased antifungal drug resistance that are difficult to treat with a limited antifungal repertoire. Some adjuvant treatments have been investigated, such as photodynamic therapy (PDT), which employs a photosensitizer (PS) irradiated by light. However, most PSs available suffer from poor biofilm penetration. In this in vitro study, a nanocarrier system was proposed as a possible strategy to facilitate the methylene blue (MB) photosensitizer penetration into biofilm and improve PDT action against C. auris. For this, positively (MB-P) and negatively (MB-N) charged liposomes encapsulating MB were success

SUBMITTER: Nagai de Lima PM 

PROVIDER: S-EPMC12797236 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature