Effects of gender-affirming hormone therapy from adolescence to adulthood on bone mineral density, body composition and muscle strength.

ABSTRACT:

Background

The number of transgender and gender-diverse (TGD) minors seeking medical care continues to increase, however data on long-term effects of gender-affirming hormone therapy (GAHT) started in adolescence remain limited.

Methods

This single center study (Ghent University Hospital, Belgium) included a cohort of TGD individuals registered female at birth (RFAB, n = 91) and registered male at birth (RMAB, n = 26) who commenced GAHT during adolescence and were followed into adulthood for up to 10 years. Participants were enrolled retrospectively between September 2023 and December 2024. Outcomes assessed cross-sectionally included areal bone mineral density (aBMD), body composition, handgrip strength, and overall life satisfaction. Lifestyle factors such as alcohol and t

SUBMITTER: Ciancia S 

PROVIDER: S-EPMC12803899 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature