Predictive potential of patient-specific immunological characteristics in solid cancers: circulating monocytes, myeloid-derived suppressor cells, T cells, and the T-cell receptor repertoire.

ABSTRACT:

Background

Response prediction to immune checkpoint inhibitors (ICIs) relies on tumor-specific biomarkers, while patient-specific characteristics are underrepresented. Therefore, we explored patient-specific immunological characteristics, including peripheral monocytes, myeloid-derived suppressor cells (MDSCs), T cells, and the T-cell receptor (TCR) repertoire, to investigate associations with survival and therapy response.

Patients and methods

Patients with solid tumors were prospectively recruited to explore the association of absolute lymphocyte and monocyte counts, leukocyte-to-lymphocyte ratio (LLR), and monocyte-to-lymphocyte ratio (MLR) with overall survival (OS). Monocytes, MDSCs, T cells, and the TCR repertoire were characterized before therapy start (baseline) and,

SUBMITTER: Zierfuss C 

PROVIDER: S-EPMC12804612 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature