Metabolomic Insights Into the Impact of a Maternal Western-Style Diet and Leptin Supplementation During Suckling on Adult Rat Offspring.

ABSTRACT: Perinatal nutrition influences offspring metabolic phenotype and obesity risk. This study examines how a maternal obesogenic diet and offspring's leptin supplementation during suckling affect the metabolome in offspring adulthood, offering insights into long-term metabolic programming. Offspring of dams fed a standard diet (SD), a Western-style diet (WD) before and during gestation and lactation (WD-dams), or a WD switched to SD during lactation were supplemented throughout suckling with leptin or vehicle and then maintained on an SD post-weaning. Metabolomic analysis of plasma from offspring adult animals revealed sex-specific alterations in the relative abundance of circulating metabolites due to maternal WD. Among these, lower abundance of orotic acid in males and arginine in females em

SUBMITTER: Pomar CA 

PROVIDER: S-EPMC12805928 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature