Induction of Type I Interferon-Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes by UV Light Exposure.

ABSTRACT:

Objective

Photosensitivity occurs in ~75% of patients with lupus. Although UV light radiation (UVR) stimulates type I interferon (IFN-I) in the skin, how UVR-induced skin inflammation leads to downstream effects is poorly understood. Tissue inflammation causes dendritic cells (DCs) to migrate from organs to draining lymph nodes (dLN), including a recently identified inflammatory conventional DC subset (inf cDC2) that are potent antigen-presenting cells. To explore links between UVR and the early immune response, we examined DC and lymphocyte subset migration to dLN in normal and lupus-prone mouse strains as well as the role of IFN-I.

Methods

Mice received a single dose of UV (500 mJ/cm²) on the dorsal skin. Brachial and inguinal dLN were harvested at one or two da

SUBMITTER: Sun X 

PROVIDER: S-EPMC12807450 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature