Ex Vivo Assessment of Keratinocytic Carcinomas Using a Fast Mid-Infrared Probe.

ABSTRACT: A fast mid-infrared spectral probe was used to record infrared (IR) spectra of fresh skin tissue removed from patients with biopsy-proven keratinocytic cancer (KC) during Mohs surgery. A 150-patient library of IR spectral data was obtained to see if KC on the epidermal side (outside) of tissue samples can be differentiated from adjacent nonmalignant tissue and normal skin. A linear support vector machine model minimized overtraining predicting the contributions to decisions at each step in the spectrum. Training with an equal cost for KC and nontumor cases samples demonstrated a KC sensitivity of 93% ± 5% and specificity 82% ± 6% (threefold testing esd) on the full library. Success in this test problem warrants future studies to see if differentiation of melanoma from benign melanocytic as

SUBMITTER: Vazquez de Vasquez MG 

PROVIDER: S-EPMC12807626 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature