Development and validation of the LC-MS/MS method based on self-made purification column for simultaneous determination of novel organophosphate esters in rice-based products.

ABSTRACT: Organophosphate esters (OPEs), as commonly used flame retardant and plasticizer, emerging organic pollutants, exhibit concerning contamination levels, particularly in widely consumed rice-based foods. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for simultaneous determination of 5 OPEs in rice-based products. According to recoveries and matrix effects as indicators, quality and proportion of different purification fillers were mainly optimized to fabricate a purification cartridge, simplifying and reducing the pre-treatment process and cost. The proposed method showed excellent linearity (0.08-500 μg kg^-1, with all correlation coefficients exceeding 0.99), with improved method detection and quantification limit (MDL and MQL): 0.0047-0.1309 and

SUBMITTER: Zhou H 

PROVIDER: S-EPMC12807793 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature