Shikonin-loaded porous graphdiyne nanofilm on titanium surface for enhanced antibacterial activity and osseointegration.

ABSTRACT: Bacterial infection, peri-implant inflammation, and poor osseointegration are primary causes of failure in titanium (Ti)-based implants. Surface functionalization provides a simple and effective strategy to overcome these challenges. In this study, we developed a multifunctional coating based on porous graphdiyne (GDY) nanofilm loaded with shikonin (Skn). GDY was synthesized on Ti surfaces via a copper-catalyzed reaction to form a porous nanostructure. Following Skn loading, a composite layer of tannic acid (TA) and poly (N-isopropylacrylamide) (pNIPAM) was applied, resulting in the Ti-GDY@Skn-TP system. Upon near-infrared (NIR) irradiation, the GDY coating induced localized photothermal effects sufficient to eradicate bacteria. Concurrently, the thermo-responsive release of

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12808909 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature