Temporal molecular remodeling of T cells informs their possible adaptation in 4T1 tumors.

ABSTRACT:

Background

The triple-negative breast cancer (TNBC) microenvironment undergoes progressive reprogramming, transitioning from an early immune-active state to a late immune-suppressed state. While tumor cell plasticity has been extensively studied, the temporal molecular remodeling of T cells in vivo remains poorly defined.

Results

Transcriptional analysis of T cells within 4T1 TNBC tumors, harvested at one-, three-, and six-weeks post-tumor implantation in the mammary fat pads of BALB/c mice, revealed a decline in transcriptomic signatures associated with T cells from 194 at one week to 156 at six weeks, with a significant late-stage loss or reduction of transcripts related to T cell receptors (TCR), natural killer T, and gamma delta T cells. Furthermore, changes in va

SUBMITTER: Iftehimul M 

PROVIDER: S-EPMC12809272 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature