Increased first-trimester CA125 levels associated with the development of preeclampsia.

ABSTRACT:

Background

Preeclampsia (PE) remains a leading cause of maternal and fetal mortality, necessitating reliable first-trimester biomarkers for early identification and pathogenesis elucidation. This study aimed to evaluate the predictive performance of first-trimester serum CA125 for the PE development and to examine their longitudinal associations with blood pressure trajectories during pregnancy.

Methods

A nested case-control study was conducted within the prospective BiCoS cohort, including 70 PE cases and 70 matched controls. Serum CA125 levels were measured at 12.26 ± 0.44 weeks of gestation and compared using independent t-tests. Logistic regression models were built to assess the predictive performance of CA125 alone, clinical factors, and their combination. Model discri

SUBMITTER: Yin A 

PROVIDER: S-EPMC12822124 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature