Cardamonin induces apoptosis of colorectal cancer cells via targeted inhibition of the JAK/STAT3/epithelial-mesenchymal transition (EMT) signaling axis.

ABSTRACT:

Background

Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. Cardamonin (CDN), a bioactive flavonoid derived from the seeds of Alpinia katsumadai Hayata, has demonstrated broad-spectrum anticancer potential. However, its specific mechanisms and therapeutic targets in CRC remain poorly elucidated.

Methods

Network pharmacology and molecular docking were employed to identify signaling pathways and targets associated with the anti-CRC activity of CDN. Cell viability, proliferation, migration, and invasion were evaluated using CCK-8, EdU, wound healing, and Transwell assays, respectively. Apoptosis and cell cycle were analyzed by flow cytometry. Proteomic profiling was applied to explore the underlying mechanisms, and the

SUBMITTER: Wu M 

PROVIDER: S-EPMC12823903 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature