Stage IVB ovarian carcinosarcoma in BRCA wild-type patients: two case reports of unexpected long-term remission.

ABSTRACT:

Background

Ovarian carcinosarcoma (OCS), also known as malignant mixed Müllerian tumor, is a rare and highly aggressive subtype of epithelial ovarian cancer, accounting for less than 4% of all cases. It typically presents at advanced stages and is associated with dismal outcomes, with a five-year survival rate below 30%. Despite improvements in cytoreductive surgery and systemic therapies, long-term survival in stage IV disease remains exceedingly uncommon.

Case presentation

We report two exceptional cases of stage IVB Müllerian carcinosarcoma occurring in BRCA wild-type postmenopausal women who achieved prolonged complete remission exceeding five years after multimodal management. The first patient, aged 61, presented with bilateral adnexal masses and a solitary pulmonary m

SUBMITTER: De Tommasi O 

PROVIDER: S-EPMC12827093 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature