Advances in ovarian cancer: biological insights, therapeutic innovations, and future perspectives.

ABSTRACT: Ovarian cancer (OC) remains a highly lethal gynecologic malignancy characterized by substantial molecular heterogeneity and diagnostic challenges. Although many reviews examine specific aspects of OC biology or treatment, few attempt to connect recent findings into a broader and coherent picture. This review provides an integrated and forward-looking synthesis of emerging mechanisms and therapeutic trends in OC, understanding OC progression and therapeutic resistance. Unique contributions of this review include providing a unified interpretation of emerging multi-omics evidence that reshapes the biological understanding of individual OC histotypes, delineating key metabolic dependencies such as glutamine addiction, aberrant lipid remodeling, glycolytic plasticity and purine pathway rewirin

SUBMITTER: Ma X 

PROVIDER: S-EPMC12829294 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature