Rates and risk factors of oocyte immaturity: toward personalized selection for rescue in vitro maturation.

ABSTRACT:

Purpose

To identify treatment-related factors influencing low oocyte maturation rates in standard ovarian stimulation (OS) cycles and patients' candidates for clinical studies on rescue-IVM.

Methods

Retrospective study including retrievals with ≥ 1 cumulus-oocyte-complex (COC; years: 2008-2022). The weighted-mean immaturityrate (19%) was defined in the whole dataset (N = 16,155). Variables associated with immaturity rates and warning limit (defined as weighted average + 2SD) were appraised among first retrievals with ≥ 5 COCs (N = 7962). Of the patients undergoing a first oocyte pick-up, 667 completed three retrieval cycles, enabling evaluation of the true prevalence of patients exceeding the immaturity rate warning threshold over multiple cycles.

Results

Factors infl

SUBMITTER: Taggi M 

PROVIDER: S-EPMC12831772 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature