Thyroid function status and heterogeneity of efficacy of maintenance cognitive stimulation in late-life dementia: a stratified observational study of subclinical hypothyroidism/hyperthyroidism.

ABSTRACT:

Background

Cognitive stimulation therapy (CST) and its maintenance phase (MCST) can benefit dementia. We evaluated treatment-effect heterogeneity by euthyroid versus subclinical hypothyroidism/hyperthyroidism during the 16-week maintenance period following CST.

Methods

We conducted a prospective single-center cohort embedded in routine CST to MCST. All entrants to 7-week CST were assessed at baseline/8/16/24 weeks. Sixteen-week MCST occurred per usual care. Baseline TSH/FT4/FT3 are classified as euthyroid, subclinical hypothyroidism (SCH), or hyperthyroidism (SHyper). Co-primary outcomes were 24-week Montreal Cognitive Assessment (MoCA) and Zarit changes. We used doubly robust inverse-probability-of-treatment weighting combined with linear mixed-effects models to test MCST×t

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12832453 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature