CTE neuropathology alone is associated with dementia and cognitive symptoms.

ABSTRACT:

Introduction

This studyexamined the independent contribution of chronic traumatic encephalopathy (CTE) neuropathology to symptoms.

Methods

The sample included 614 brain donors with (n = 366) and without (n = 248) autopsy-confirmed CTE. Brain donors with other major neurodegenerative disease diagnoses were excluded. Informants completed cognitive and neuropsychiatric measures. Dementia was determined during diagnostic consensus conferences.

Results

CTE stage IV (of IV) was associated with 4.48 (95% confidence interval [CI] = 1.97-10.90) increased odds of having dementia. CTE stage III had an odds ratio of 2.12 (95% CI = 1.91-3.77). Higher CTE stage was associated with greater informant-reported cognitive symptoms (p < 0.01). There were no associations with mood/behavio

SUBMITTER: Layden RM 

PROVIDER: S-EPMC12836376 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature