Exploratory analysis of the impact of sex on sputum proteomic response to inhaled wood smoke in humans.

ABSTRACT: Wildfires have surged in frequency and severity, and in 2022, they contributed to nearly 30% of the fine inhalable particulate matter (PM2.5) in the United States. Health effects from wildfire-induced wood smoke (WS) exposure include worsened pre-existing lung diseases and lung function, increased emergency room visits, and increased risk of premature death. Evidence suggests that males and females have unique responses to air pollutants, but sex-specific responses to WS remain understudied. To evaluate whether males and females differentially respond to WS, we analyzed induced sputum samples in humans following a controlled chamber exposure to WS. A total of 79 participants were exposed to 500 µg/m3 of WS for 2 h with intermittent exercise, and a subset of participants' samples were analy

SUBMITTER: Nalesnik M 

PROVIDER: S-EPMC12844565 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature