Safety and efficacy of pulsed field ablation versus cryoablation for atrial fibrillation: A comprehensive meta-analysis.

ABSTRACT:

Background

Atrial fibrillation (AF) remains the most common sustained cardiac arrhythmia. Pulsed field ablation (PFA) and cryoablation (CA) aim to isolate pulmonary veins and prevent AF recurrence. This meta-analysis aims to provide a comprehensive comparison of PFA and CA in treatment of AF in context of efficacy, procedural characteristics, and safety profiles.

Methods

A comprehensive literature search of databases (PubMed, Cochrane Library, Science Direct and Google Scholar) was conducted from their inception to September 2024. Statistical analyses were conducted using Cochrane's RevMan 5.4 software.

Results

Twenty studies (n = 4638; PFA = 2172, CA = 3033) were included in this meta-analysis. Regarding efficacy outcomes, PFA significantly reduced AF recurrence (odd

SUBMITTER: Bokhari SFH 

PROVIDER: S-EPMC12851682 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature