Heterogeneous photocatalytic C4 remote fluorosulfonamidation of pyridines.

ABSTRACT: N-Fluorosulfamoyl pyridinium salts have been ingeniously developed as redox-active precursors for generating fluorosulfamoyl radicals. However, the ubiquitous pyridine scaffold within these compounds, commonplace in numerous pharmaceuticals, has remained being wasted in reported methods only as a radical leaving group. This underutilization presents both a significant challenge and an exciting opportunity for further research in synthetic, medicinal, and materials chemistry. Herein, N-fluorosulfamoyl pyridinium salts were employed as bifunctional reagents to achieve remote and selective C-H functionalization of pyridines through a radical relay process that enables polarity reversal of radical intermediates. By employing ZnIn₂S₄ as a heterogeneous photoc

SUBMITTER: Xiang P 

PROVIDER: S-EPMC12853103 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature