Timing of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3-Inflammasome Activation in Macrophages.

ABSTRACT: Glucocorticoids (GCs) are lifesaving medicines prescribed to treat inflammatory diseases. Macrophages play a pivotal role during hyperinflammation and cytokine storm, two processes intricately linked to NLRP3 inflammasome activation. Macrophages undergo a process of transcriptional reprogramming to resolve inflammation and restore homeostasis. We hypothesized that glucocorticoid receptor (GR) signaling contributes to macrophage metabolic reprogramming to overcome the NLRP3-inflammasome activation through genomic effects induced by GCs. Glucocorticoid administration following prolonged exposure to lipopolysaccharide (LPS) decreases the expression of iNOS and ACOD1 and their respective metabolic products, nitric oxide and itaconate, to maintain an intact tricarboxylic acid (TCA) cycle in WT

SUBMITTER: Diaz-Jimenez D 

PROVIDER: S-EPMC12862736 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature