Synthesis and antitumor activity of mono and digold(i) alkynyl complexes with oligo(ethylene glycol)methylether.

ABSTRACT: Preparation and characterization of a series of oligo(ethylene glycol)methylether functionalized alkynyl gold(i) complexes capped with AuPPh₃ (1a-1d) or dppfAu₂ (dppf, 1,1'-bis(diphenyphosphino)ferrocene) (2a-2d) have been accomplished. The structures of 1b and 1c were established by X-ray crystallography. Their in vitro antitumor activities were measured by the CCK8 method against A549 and HeLa cells. The studies indicated that the cytotoxic activity in vitro was fine-tuned by modification of both the gold(i) centers and the oligo(ethylene glycol)methylether ancillary ligands. Compared to the dppfAu₂ series, the AuPPh₃ series showed better cytotoxicity. Especially, complex 4-(OCH₂CH₂OCH₂CH

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC12865784 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature