Functional Connectivity Predictors and Mechanisms of Symptom Change in Functional Neurological Disorder.

ABSTRACT:

Background

Clinical trajectories in functional neurological disorder (FND) are variable, and the mechanisms underlying this heterogeneity remain poorly understood.

Objective

This longitudinal study examined resting-state functional connectivity predictors and mechanisms of symptom change in FND.

Methods

Thirty-two adults with FND (motor and/or seizure phenotypes) completed baseline questionnaires and a functional MRI (fMRI) session, followed by naturalistic treatment for 6.8±0.8 months. All participants completed follow-up questionnaires; 28 individuals completed a follow-up fMRI. At each timepoint, three graph-theory network metrics of functional connectivity were computed: weighted-degree (centrality), integration (between-network connectivity), and segregati

SUBMITTER: Westlin C 

PROVIDER: S-EPMC12870675 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature