Circulating thyroid hormones and metabolites in children with autism spectrum disorder.

ABSTRACT:

Context

Thyroid hormones affect neurological development and function, but detailed studies of thyroid hormones and metabolites in autism are lacking.

Objective

To characterize thyroid function and metabolism in autistic children.

Methodology

This cross-sectional study compared 788 autistic children (mean age 7.6 ± 3.9 years, 78% male) with 301 non-autistic children (mean age 7.8 ± 4.0 years, 48% male; comprising 215 (71.4%) non-autistic siblings of participants and 86 (28.6%) unrelated individuals). Plasma TSH, free T4 (FT4) and free T3 (FT3) were measured by automated immunoassay, and total T4, total T3 and thyroid hormone metabolites by customized liquid chromatography-tandem mass spectrometry (LCMS/MS). Regression analyses were adjusted for age and sex.

Results

SUBMITTER: Hancock M 

PROVIDER: S-EPMC12872564 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature