Oral immunization with <i>Listeria monocytogenes</i> vaccine enhances immunotherapy for protective immunity in murine models of colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a leading cause of cancer-related death and remains a significant global health challenge. Cancer vaccines have emerged as a promising immunotherapy for long-term tumor control. While Listeria monocytogenes (Lm)-based intravenous vaccines can generate tumor-reactive CD8 T cells, clinical trial success has been limited. Here, we sought to determine whether in vivo targeting of gastrointestinal tissues with foodborne delivery of Lm-based cancer vaccines controlled tumor growth in murine models of CRC.

Methods

The ActA and InlB virulence genes were deleted from a mouse-adapted Lm strain expressing ovalbumin and containing an internalin A mutation (InlA^M Lm-ova) that allows epithelial cell

SUBMITTER: Lei X 

PROVIDER: S-EPMC12878199 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature