<i>Enterococcus faecium</i> secreted the NlpC/P60 family protein to enhance host immunity and indirectly increases <i>Akkermansia muciniphila</i> for slowing aging.

ABSTRACT: While probiotics like Enterococcus faecium are known for gut health benefits, their potential anti-aging effects are poorly understood. This study investigated whether E. faecium fermentation broth delays aging and explored its mechanisms. Using a mouse model, lifespan assays suggested that the E. faecium fermentation broth may contribute to lifespan extension, indicating anti-aging properties. Microbiome analysis showed it modulated gut microbiota, increasing beneficial Akkermansia abundance. Key active components identified included myo-inositol (promoting hair follicle growth), D-ribose, and secreted proteins. While myo-inositol increased the abundance of Lactobacillus reuteri and Lactobacillus johnsonii, it did not increase Akkermansia.

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12894319 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature