Exopolysaccharides from <i>Lacticaseibacillus rhamnosus</i> Fmb14 Ameliorate Fructose-Induced Hyperuricemia and Fatty Liver via Gut Modulation.

ABSTRACT: Fructose dietary intake is one of the most common risk factors for hyperuricemia, which is a critical threat to human health, and the lack of an effective biological intervention method is the main problem in preventing hyperuricemia caused by fructose intake. Lacticaseibacillus rhamnosus Fmb14 (L. rhamnosus Fmb14) has a fructose-metabolizing ability to produce extracellular polysaccharides (EPSs), and the yield of EPSs reached 0.50 and 0.42 g/L after 48 h of fermentation in liquid media of glucose-MRS and fructose-MRS. Six pure polysaccharide components were obtained after purification. A hyperuricemic mouse model was subsequently established by feeding a 60% high-fructose diet with potassium oxyazinate for 8 weeks, and the results revealed that L. rhamnosus Fmb14 and

SUBMITTER: Zhao H 

PROVIDER: S-EPMC12896772 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature