Random interval schedule of reinforcement influences punishment resistance for cocaine in rats.

ABSTRACT: In an animal model of compulsive drug use, a subset of rats continues to self-administer cocaine despite footshock consequences and is considered punishment resistant. We recently found that punishment resistance is associated with habits that persist under conditions that typically encourage a transition to goal-directed control. Given that random ratio (RR) and random interval (RI) schedules of reinforcement influence whether responding is goal-directed or habitual, we investigated the influence of these schedules on punishment resistance for cocaine or food. Male and female Sprague Dawley rats were trained to self-administer either intravenous cocaine or food pellets on a seeking-taking chained schedule of reinforcement, with the seeking lever requiring completion of either an RR20 or R

SUBMITTER: Jones BO 

PROVIDER: S-EPMC12904990 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature