IFN-γ Driven Hepatic Injury Exacerbates Mortality in NK/T-Cell Lymphoma-Associated Hemophagocytic Lymphohistiocytosis.

ABSTRACT:

Background

Hepatic involvement is a life-threatening complication in natural killer/T-cell lymphoma with hemophagocytic lymphohistiocytosis (NK/T-HLH). Nevertheless, the prognostic implications of hepatic dysfunction and its underlying related factors are not fully elucidated.

Methods

We retrospectively analyzed the clinical and laboratory data of 53 NK/T patients, comprising 35 cases without HLH and 18 with HLH. All NK/T-HLH patients exhibited hepatic injury, characterized by significantly elevated hepatic enzyme levels and bilirubin compared to those without HLH (all p < 0.001). Glutamyltransferase (GGT), aspartate aminotransferase (AST), and direct bilirubin (DBIL) individually predicted mortality with AUC > 0.8 in NKTCL patients, while their composite GSD index enhanced

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12906978 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature