Research Note: The Association Between Parity and Odds of Alzheimer's Disease and Dementias Status.

ABSTRACT: While parity is a significant factor influencing parental health, its relationship with dementia remains underexplored. This research note advances the literature by conducting a well-powered analysis of associations between parity (i.e., number of children) and Alzheimer's disease and dementias (AD/D) status in large-scale population data. The data contain a large number of AD/D cases (37,228 women and 19,846 men), allowing a range (1-10) of parity associations to be estimated precisely. Using proxy (adult child's) reports of parental AD/D status, we find that both fathers and mothers with grand multiparity have decreased odds of AD/D status, and the effect sizes become larger as parity increases, with 30-40% reduction in AD/D status at parities above 7. The association is stronger for mo

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12907878 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature