Exploring the causal relationship between COPD and AKI: A bidirectional Mendelian randomization approach.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) and acute kidney injury (AKI) are significant public health burdens, and emerging observational studies have suggested a potential link between them. However, causality remains unclear. This study aimed to investigate the causal relationship between COPD and AKI using two-sample Mendelian randomization (MR) analyses. We utilized 11 independent single-nucleotide polymorphisms associated with COPD to perform two-sample MR analyses on 2 AKI datasets (GCST90018790 and ACUTERENFAIL). Inverse variance weighted (IVW), weighted median, MR-Egger, and weighted mode methods were employed to estimate causal effects. Sensitivity analyses included MR-Egger intercept tests for directional pleiotropy and Cochran Q tests for heterogeneity. A reverse MR analysis

SUBMITTER: Ma H 

PROVIDER: S-EPMC12908769 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature