Twin and Cotwin Predictors of Fetal Demise After Laser Photocoagulation Therapy in Advanced Stage Twin-Twin Transfusion Syndrome: A Fetal Heart Society Research Collaborative Study.

ABSTRACT:

Background

Current models to predict outcomes in advanced twin-twin transfusion syndrome are limited. We hypothesized that twin and cotwin echocardiographic factors would improve model performance for donor and recipient demise following laser photocoagulation therapy.

Methods

We performed a multicenter retrospective cohort study of stage 3 to 4 twin-twin transfusion syndrome referred for laser photocoagulation therapy. Fetal echocardiograms were analyzed at a core laboratory. We used multivariable logistic regression models to select variables used for generalized linear mixed-effects modeling. Separate models were developed for donor and recipient demise, using both twin and cotwin variables. Models were assessed by area under the receiver operating characteristic curves.<

SUBMITTER: Maskatia SA 

PROVIDER: S-EPMC12909029 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature