Osteoporosis and cardiac remodeling in middle-aged and older adults: a cross-sectional study.

ABSTRACT: Osteoporosis is associated with cardiovascular disease, but the relationship between bone mineral density (BMD) and cardiac structure and function remains incompletely understood. This cross-sectional study analyzed baseline data from 1233 participants (median age 60 years; 59% female) in the Osteoarthritis and Cardiovascular Health Cohort. BMD was categorized as normal (T-score ≥ - 1.0, n = 364), osteopenia (- 2.5 < T-score < - 1.0, n = 404), or osteoporosis (T-score ≤ - 2.5, n = 465). Cardiac parameters were measured via echocardiography. Multivariable linear regression adjusted for age, sex, and cardiovascular risk factors. Osteoporosis was associated with higher LAVI (median: 29 vs. 26 mL/m², P < 0.001) and RWT (0.38 vs. 0.37, P = 0.047) compared to normal BMD. After adjustm

SUBMITTER: Wang H 

PROVIDER: S-EPMC12910028 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature