<i>Holdemanella biformis</i> augments washed microbiota transplantation for the treatment of radiation enteritis.

ABSTRACT:

Background

Current microbiome-based therapeutics face two prominent issues: the limited clinical efficacy of probiotics and the significant variability in the efficacy of microbiota transplantation across different diseases. Although washed microbiota transplantation (WMT) is a new faecal microbiota transplantation, a single therapeutic agent cannot be universally effective for multiple dysbiosis-related diseases.

Objective

We introduced a new therapeutic concept, X-augmented WMT (X-auWMT), which combines a disease-specific beneficial microbe, 'X', with WMT to enhance its effectiveness. Our goal was to identify a candidate 'X' bacterium to augment WMT efficacy and examine the efficacy of X-auWMT in animal models of radiation enteritis (RE).

Design

We conducted a prosp

SUBMITTER: Wang W 

PROVIDER: S-EPMC12911655 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature