Disease modulation by TIV vaccination during secondary pneumococcal infections in influenza-infected mice.

ABSTRACT: Secondary bacterial infections can significantly worsen the clinical course of influenza virus infections and are a leading cause of morbidity and mortality during seasonal influenza epidemics. Despite being a vaccine-preventable disease, influenza-related complications from secondary bacterial infections are an important cause of death, particularly among the elderly population. Streptococcus pneumoniae (Spn) is the most common agent responsible for influenza-related secondary bacterial infections. Influenza virus vaccination serves as an effective prophylactic strategy for preventing influenza and reducing the burden of influenza-associated pathology, including secondary bacterial infection. However, whether the protective effects of influenza virus vaccination differ in the conte

SUBMITTER: Diego JG-B 

PROVIDER: S-EPMC12911902 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature