Vascular basement membrane laminins modulate functional zonation of cerebral microvessels.

ABSTRACT: We investigated whether basement membrane (BM) laminins influence regional differences in the vasculature by performing single-cell RNA sequencing on cerebral blood vessels from mice lacking the major vascular laminins in endothelial and smooth muscle BMs, laminin α4 (Lama4^-/- ) and laminin α5 (Tek-cre:Lama5^-/-), and wild-type littermates. Our dataset expands existing cerebral vascular transcriptomic profiles and reveals that Lama4^-/- endothelial cells exhibit increased arterial marker expression and reduced postcapillary venule identity. In vitro and in vivo studies indicated that compensatory upregulation of laminin α5 in Lama4^-/- vessels enhance

SUBMITTER: Deshpande T 

PROVIDER: S-EPMC12913041 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature