Quantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized ¹²⁹Xe Gas Exchange Magnetic Resonance Imaging.

ABSTRACT:

Purpose

Radiation-induced lung injury has been shown to alter regional ventilation and perfusion in the lung. However, changes in regional pulmonary gas exchange have not previously been measured.

Methods and materials

Ten patients receiving conventional radiation therapy (RT) for lung cancer underwent pre-RT and 3-month post-RT magnetic resonance imaging (MRI) using an established hyperpolarized ¹²⁹Xe gas exchange technique to map lung function. Four patients underwent an additional 8-month post-RT MRI. The MR signal from inhaled xenon was measured in the following 3 pulmonary compartments: the lung airspaces, the alveolar membrane tissue, and the pulmonary capillaries (interacting with red blood cells [RBCs]). Thoracic ¹H MRI scans were acquired, and

SUBMITTER: Rankine LJ 

PROVIDER: S-EPMC12914451 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature