Altered Neurobehavioral Reward Response Predicts Psychotic-Like Experiences in Youth Exposed to Cannabis Prenatally.

ABSTRACT:

Background

Rates of prenatal cannabis exposure (PCE) are rising with increasingly permissive legislation, which may be a risk factor for psychosis. Disrupted reward-related neural circuitry may underlie this relationship. We aim to elucidate neural mechanisms involved in the association between PCE and youth-onset psychotic-like experiences (PLEs) by probing correlates of reward anticipation, a neurobehavioral marker of endocannabinoid-mediated dopaminergic function.

Methods

This longitudinal, prospective study analyzed task-related functional neuroimaging data from baseline (N = 11,368), 2-year follow-up (n = 7928), and 4-year follow-up (n = 2982) of the ongoing ABCD (Adolescent Brain Cognitive Development) Study, which recruited children ages 9 to 10 years at baseline from

SUBMITTER: Amir CM 

PROVIDER: S-EPMC12915486 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature