Myeloid landscape profiling identifies DLBCL-specific suppressive macrophages colocalized with blood endothelial cells.

ABSTRACT:

Abstract

Diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) are the 2 most common B-cell lymphomas and are characterized by a dynamic crosstalk between tumor B cells and a heterogeneous, tumor-supportive microenvironment, such as immune, endothelial, and stromal components. Despite their recognized impact on the pathogenesis and prognosis of B-cell lymphoma, tumor-associated macrophages (TAM) have not been extensively explored in these diseases. In this study, we investigated mononuclear phagocyte (MNP) heterogeneity at the single-cell level and the activation profile of MNP, stromal, and endothelial compartments, in B-cell lymphoma lymph nodes compared to reactive secondary lymphoid organs. This was achieved using a combination of mass cytometry, single-cell RNA se

SUBMITTER: Ferrant J 

PROVIDER: S-EPMC12917531 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature