By Chance, Not Design: A New Furosemide Derivative From Zinc(II) Complex Studies.

ABSTRACT: Furosemide, a sulfonamide-based diuretic, may also be of interest as a ligand capable of binding to metal ions. Our studies of zinc-(II) coordination chemistry with furosemide in organic solvents resulted in a crystalline precipitate. Initial characterization was challenging because single crystals were of insufficient quality for an unambiguous structural determination. X-ray analysis confirmed a four-coordinate zinc-(II) complex with two deprotonated furosemides (fur^-) bound in a monodentate manner and two simple monodentate ligands. Complementary techniques, i.e., infrared spectroscopy, NMR spectroscopy, and thermal analysis, revealed their identity as ammonia, generated in situ from acetonitrile hydrolysis. The composition of the product is thus [Zn-(fur)₂(

SUBMITTER: Podjed Rihtarsic N 

PROVIDER: S-EPMC12917693 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature