Neuronal mechanisms underlying binaural performance with cochlear implant in single-sided deafness: a [¹⁵O]water PET study.

ABSTRACT:

Purpose

We examined neuronal activation patterns in single-sided deaf (SSD) cochlear implant (CI) recipients and normal-hearing (NH) controls to unravel neuronal mechanisms underlying binaural integration in SSD-CI.

Methods

20 SSD-CI (CI left) and 10 NH controls underwent [¹⁵O]water PET (assessing relative cerebral blood flow, rCBF) during auditory stimulation (forward or time-reversed, unilaterally to NH ear or bilaterally). Subjects were divided into SSD-CI with good (≥ 80%) and poor (< 80%) performance based on a median split of correct word understanding in PET background noise. Voxel-wise analyses identified volumes of interest for regional analyses (right primary auditory cortex (PAC), left superior temporal gyrus (STG)) for volume-of-interest analyses.

R

SUBMITTER: Speck I 

PROVIDER: S-EPMC12920324 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature