Sex- and Age-Stratified Outcomes of Colonoscopy Versus Faecal Immunochemical Testing: Post-Analysis of the COLONPREV Study.

ABSTRACT:

Background

Colorectal cancer (CRC) screening is effective and cost-effective in average-risk individuals. The COLONPREV study recently showed that individuals invited to a faecal immunochemical test (FIT) were more likely to participate in screening than those invited to colonoscopy, and that FIT-based screening was non-inferior to colonoscopy with respect to CRC-related mortality and CRC incidence.

Objective

To assess whether the outcomes of colonoscopy- and FIT-based screening differ according to sex and age in the invited population.

Methods

Presumptively healthy men and women aged 50-69 years were randomised to either a one-time screening colonoscopy or biennial FIT. In this analysis, we report participation and crossover rates, CRC-related mortality, CRC incidenc

SUBMITTER: Castells A 

PROVIDER: S-EPMC12920682 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature