Structural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor.

ABSTRACT: Cerebellar mutism syndrome (CMS) is a potential complication of pediatric posterior fossa tumor (pPFT) resection and may be related to disruption of the dentato-rubro-thalamic tract (DRTT). Intraoperative tractography allows assessment of changes to the DRTT during surgery. We evaluated macro- and microstructural changes of the DRTT by comparing pre- and intraoperative diffusion MRI (dMRI) tractography in patients with pPFT. Pre- and intraoperative T1-weighted and dMRI data were acquired to reconstruct the DRTT, while the arcuate fasciculus (AF) was reconstructed as a control tract. To evaluate macrostructural intraoperative alterations, tract volume and diameter were calculated. Microstructural changes were assessed using fractional anisotropy (FA) and mean diffusivity (MD), both globally

SUBMITTER: Jellema PEJ 

PROVIDER: S-EPMC12923661 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature